Proteínas homólogas
Proteínas homólogas ao FTO (via BLASTp):
As proteínas homólogas ao FTO são proteínas de outras espécies que partilham uma origem evolutiva comum com à proteína e apresentam semelhanças na sequência de aminoácidos e/ou estrutura.
1. Homo sapiens (Humano)
seq ref: NP_001073901.1 [Homo sapiens]
percent identity: 100%
FASTA:>sp|Q9C0B1|FTO_HUMAN alpha-ketoglutarate-dependent dioxygenase FTO isoform 3 [Homo sapiens]
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
2. Pan paniscus (Bonobo)
seq ref: XP_024781684.1 [Pan paniscus]
percent identity: 99.80%
FASTA:>XP_024781684.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X2 [Pan paniscus]
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFL
TLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFL
KLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQ
KMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDI
ETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVD
NDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPMEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLT
DIVSELRGQLLEAKP
3. Hylobates moloch (Gibão-prateado)
seq ref: XP_032013254.1 [Hylobates moloch]
percent identity: 99.60%
FASTA:>XP_032013254.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X2 [Hylobates moloch]
MGVVVFSTLRENGSGREQDAERTTCRRRSPGRGIYAACGGEGGFSGSMKRTPTAEEREREAKKLRLLEEL
EDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTP
VSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKA
NEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHD
ENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNA
THQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNIRDDVDNDDVSLKSFEPAVLKQGEEIHNE
VEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLT
ARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP
4. Pan troglodytes (Chimpanzés)
seq ref: PNI63968.1 [Pan troglodytes]
percent identity: 99.60%
FASTA:>PNI63968.1 FTO isoform 4 [Pan troglodytes]
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFL
TLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFL
KLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQ
KMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDI
ETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVD
NDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKGEGLPMEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLT
DIVSELRGQLLEAKP
5. Nomascus leucogenys (Gibão-de-bochechas-brancas-do-norte)
seq ref: XP_003263101.1 [Nomascus leucogenys]
percent identity: 99.01%
FASTA:>XP_003263101.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X2 [Nomascus leucogenys]
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFL
TLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFL
KLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQ
KMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDI
ETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNIHDNVD
NDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARHNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLT
DIVSELRGHLLEAKP
6. Pongo pygmaeus (Orangotango-de-Bornéu)
seq ref: XP_054309496.1 [Pongo pygmaeus]
percent identity: 98.81%
FASTA:>XP_054309496.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X2 [Pongo pygmaeus]
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFL
TMHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFL
KLNDYLQIETIQALEELAAKEKANEDTVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQ
KMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDI
ETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVRDDVE
NDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEAVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDVSMPLPFDLT
DIVSELRGQLLEAKP
7. Pongo abelii (Orangotango-de-sumatra)
seq ref: PNJ62567.1 [Pongo abelii]
percent identity: 98.61%
FASTA:>PNJ62567.1 FTO isoform 3 [Pongo abelii]
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFL
TMHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFL
KLNDYLQIETIQALEELAAKEKANEDTVPLCMSADFPRVGMGSSYNGQDEVDVKSRAAYNVTLLNFMDPQ
KMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDI
ETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVRDDVE
NDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEAVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDVSMPLPFDLT
DIVSELRGQLLEAKP
8. Cercocebus atys (Sooty Mangabey)
seq ref: XP_011921544.1 [Cercocebus atys]
percent identity: 98.42%
FASTA:>XP_011921544.1 PREDICTED: alpha-ketoglutarate-dependent dioxygenase FTO isoform X1 [Cercocebus atys]
MAPDGSRTLRELHAGGGVQGEGIYAACGGEGGFSGSMKRTPTAEEREREAKKLRLLEELEDTWLPYLTPK
DDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGC
TYKYLNTRLFTVPWPVKGSNIKYPEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSA
DFPRVGMGSSYDGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAV
YSYSCEGPEEESDDDSHFEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQ
PRFSSTHRVAECSTGTLDYILQRCQLALQNVRDDVDNGDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWF
QGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHA
RCQSRIARTLPADQKPECRPYWEKDDVSMPLPFDLTDIVSELRGQLLEAKP
9. Rhinopithecus roxellana (Macaco-dourado)
seq ref: XP_010356591.2 [Rhinopithecus roxellana]
percent identity: 98.61%
FASTA:>XP_010356591.2 alpha-ketoglutarate-dependent dioxygenase FTO isoform X1 [Rhinopithecus roxellana]
MAPDGSRTLRELHAGGGVQGEGIYAACGGEGGFSGSMKRTPTAEEREREAKKLRLLEELEDTWLPYLTPK
DDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGC
TYKYLNTRLFTVPWPVKGSNIKYPEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSA
DFPRVGMGSSYDGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAV
YSYSCEGPEEESEDDSHFEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQ
PRFSSTHRVAECSTGTLDYILQRCQLALQNVRDDVDNGDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWF
QGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHA
RCQSRIARTLPADQKPECRPYWEKDDISMPLPFDLTDIVSELRGQLLEAKP
10. Symphalangus syndactylus (Gibão Siamang)
seq ref: XP_055088665.1 [Symphalangus syndactylus]
percent identity: 95.44%
FASTA:>XP_055088665.1 LOW QUALITY PROTEIN: alpha-ketoglutarate-dependent dioxygenase FTO [Symphalangus syndactylus]
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFL
TLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFL
KLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQ
KMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDI
ETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNIHDNVD
NDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVISVKLYK
ELGLMSPRLIRHKATNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQK
PECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP